Sun's Light Most Effect Lingers After Dark

Researchers explain that UV light from the sun or tanning beds can damage DNA in melanocytes. Melanocytes are cells in the skin that make the substance called melanin. Melanin gives skin its color. Damage to melanocytes is a major cause of skin cancer, according to the researchers.Researchers exposed mouse and human melanocytes to UV radiation. In melanocytes with melanin, DNA damage occurred not only immediately, but also hours after UV exposure ended. In melanocytes that didn't have melanin, the damage occurred only during UV exposure.

"If you look inside adult skin, melanin does protect against [DNA damage]. It does act as a shield. But it is doing both good and bad things," said study author Douglas Brash in a Yale University School of Medicine news release. He is a clinical professor of therapeutic radiology and dermatology at Yale.

It was thought that melanin protected the skin by blocking UV light, but this study found that melanin has both protective and harmful effects.



Scientists explained the process that caused DNA-related damage in the dark. UV light activated enzymes that stimulated melanin. This process, called chemiexcitation, created the same DNA damage in the dark that sunlight caused in daytime, according to the researchers.

Chemiexcitation is a slow process and it may be possible to develop ways to prevent it, such as "an evening-after" sunscreen that might be able to block the transfer of damaging energy to the skin cells, the researchers said.